Clinical Trials and the Right to Remain Silent
In this issue of JAMA Internal Medicine, Kernan et al chronicle Yale University’s experience responding to a subpoena for data from an ongoing, double-blind, placebo-controlled trial of pioglitazone....
View ArticleMeasuring the Effectiveness of Androgen-Deprivation Therapy for Prostate...
In the late 1970s, investigators learned that androgen-deprivation therapy (ADT) decreased serum testosterone levels and, more importantly, reduced bone pain among men with prostate cancer. Whereas ADT...
View ArticleUnderrepresentation of Women, Elderly Patients, and Racial Minorities in the...
The American College of Cardiology/American Heart Association (ACC/AHA) guidelines are frequently used to guide cardiovascular care. Randomized controlled trials (RCTs) are considered to be the highest...
View ArticleGeographic Accessibility to Clinical Trials for Advanced Cancer in the United...
Clinical trials yield critical evidence to guide the care of patients with cancer. According to commonly used practice guidelines, “...the best management of any cancer patient is in a clinical trial.”...
View ArticleThe Strange Allure of State “Right-to-Try” Laws
State “right-to-try” laws that purport to allow patients to be treated with unapproved drugs or devices seem likely to be futile.
View ArticlePrevention Guidelines Bad Process, Bad Outcome
Thomas Jefferson, the third American President and author of the Declaration of Independence, famously opined, “Governments derive their just powers from the consent of the governed.” The principle...
View ArticleAssociation of Cardiovascular Trial Registration With Positive Study Findings...
Trial registration has been proposed to reduce selective publication and outcome reporting, thereby increasing accountability in the conduct of research. Since 2005, policy makers, journal editors, and...
View ArticleGeographic Accessibility to Clinical Trials for Advanced Cancer in the United...
Clinical trials yield critical evidence to guide the care of patients with cancer. According to commonly used practice guidelines, “...the best management of any cancer patient is in a clinical trial.”...
View ArticleResearch Misconduct Identified by the US Food and Drug Administration Out of...
ImportanceEvery year, the US Food and Drug Administration (FDA) inspects several hundred clinical sites performing biomedical research on human participants and occasionally finds evidence of...
View ArticleReporting Research Misconduct in the Medical Literature
In this issue of JAMA Internal Medicine, we publish a report that highlights an important area for improved public reporting of clinical trials and enhanced transparency at the US Food and Drug...
View ArticleCreating a List of Low-Value Health Care Activities in Swiss Primary Care
In 2010, the idea emerged of creating lists of low-value health care activities as a way to confront rising medical costs and encourage cost-conscious care. The Good Stewardship Working Group and Brody...
View ArticleDevelopment of Choosing Wisely Recommendations for an Inpatient Internal...
As part of the American Board of Internal Medicine Foundation’s Choosing Wisely campaign, more than 60 specialty societies have published lists of 5 tests, procedures, or treatments that physicians and...
View ArticlePerioperative Cardiovascular Care for Patients Undergoing Noncardiac Surgical...
The field of perioperative medicine has garnered legitimacy during the past 3 decades. Adverse cardiovascular events in the perioperative period account for significant morbidity and mortality....
View ArticleOn the Undiffusion of Established Practices
Everett Rogers’ classic monograph on the diffusion of innovations represents the process by which we adopt new ideas and practices as a smooth S-shaped curve. In this curve, the percentage of adoption...
View ArticleIntra-aortic Balloon Pump Therapy for Acute Myocardial Infarction A...
ImportanceIntra-aortic balloon pump (IABP) therapy is a widely used intervention for acute myocardial infarction with cardiogenic shock. Guidelines, which previously strongly recommended it, have...
View ArticleCreating a List of Low-Value Health Care Activities in Swiss Primary Care
In 2010, the idea emerged of creating lists of low-value health care activities as a way to confront rising medical costs and encourage cost-conscious care. The Good Stewardship Working Group and Brody...
View ArticleDevelopment of Choosing Wisely Recommendations for an Inpatient Internal...
As part of the American Board of Internal Medicine Foundation’s Choosing Wisely campaign, more than 60 specialty societies have published lists of 5 tests, procedures, or treatments that physicians and...
View ArticleResearch Misconduct Identified by the US Food and Drug Administration Out of...
ImportanceEvery year, the US Food and Drug Administration (FDA) inspects several hundred clinical sites performing biomedical research on human participants and occasionally finds evidence of...
View ArticleReporting Research Misconduct in the Medical Literature
In this issue of JAMA Internal Medicine, we publish a report that highlights an important area for improved public reporting of clinical trials and enhanced transparency at the US Food and Drug...
View ArticleIntra-Aortic Balloon Pump in Myocardial Infarction
In this meta-analysis, intra-aortic balloon pump therapy was not found to improve mortality among patients with acute myocardial infarction in randomized clinical trials, regardless of whether patients...
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